Dr Isaac Akefe
Lecturer
Academy for Medical Education
Senior Research Assistant/Technicia
Queensland Brain Institute
Researcher biography
Dr. Akefe Isaac obtained his Doctor of Veterinary Medicine (DVM) degree at the University of Abuja and Master of Science in Physiology at Ahmadu Bello University, Zaria, Nigeria. He went on to complete his PhD in molecular neuroscience at the Queensland Brain Institute, the University of Queensland, Australia, in 2022. He was awarded Fellow of the Higher Education Academy (FHEA) in 2022 and joined the Academy for Medical Education, the University of Queensland as a Lecturer/Research Fellow in 2022. Akefe is currently the course coordinator for MEDI7281 – Foundations of Medical Research Course offered to second-year medical students. Akefe Isaac is a passionate academic with a wealth of experience in implementing cutting-edge pedagogical skills via effective planning, initiation, and leading of teaching and learning in institutions of higher learning within and outside Australia. He is also an expert biomedical researcher focusing on uncovering the cellular mechanisms and/or pathways involved in the development and progression of memory impairment, and ageing dementia at the Queensland Brain Institute, the University of Queensland.
M+61410546651
W https://medicine-program.uq.edu.au/medi7281-foundations-medical-research-course
CRICOS code: 00025B
Journal Articles
Obeta, Sylvester Sunday, Ubah, Simon Azubuike, Ejiofor, Charles Ejike, Agbonu, Oluwa Adikpe, Columbus, Philemon Kwinjoh, Abah, Kenneth Owoicho, Ikpe, Alapa Baba, Bankole, Abayomi Samuel, Ezinwo, Prisca Adaoma, Itodo, Joy Iyojo, Akefe, Issac Oluwatobi, Uba, Charles Amaechi and Mailafia, Samuel (2023). The clinical effect of experimental infection with Trypanosoma congolense on Dutch belted rabbits. Parasitology Research, 122 (1), 113-116. doi: 10.1007/s00436-022-07702-5
Harakeh, Steve, Saber, Saber H., Akefe, Isaac O., Shaker, Soad, Barkaat Hussain, Muhammad, Saad Almasaudi, Arwa, Saleh, Shaimaa M.M. and Almasaudi, Saad (2022). Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi Journal of Biological Sciences, 29 (4), 3040-3050. doi: 10.1016/j.sjbs.2022.01.031
Otolorin, Gbeminiyi R., Oluwatobi, Akefe I., Olufemi, Olaolu T., Esonu, Daniel O., Dunka, Hassana I., Adanu, Williams A., Danjuma, Friday A., Abiayi, David C., Adegoke, Victoria A., Omoniwa, David O., Oghenefega, Ovwighose N. and Mshelbwala, Philip P. (2022). COVID-19 pandemic and its impacts on the environment: a global perspective. Narra J, 2 (1), 1-13. doi: 10.52225/narra.v2i1.72
Harakeh, Steve, Almuhayawi, Mohammed S., Akefe, Isaac O., Saber, Saber H., Al Jaouni, Soad K., Alzughaibi, Torki, Almehmadi, Yousef, Ali, Soad Shaker, Bharali, Dhruba J. and Mousa, Shaker (2022). Novel pomegranate-nanoparticles ameliorate cisplatin-induced nephrotoxicity and improves cisplatin anti-cancer efficacy in Ehrlich carcinoma mice model. Molecules, 27 (5) 1605, 1605. doi: 10.3390/molecules27051605
Akefe, Isaac Oluwatobi, Adegoke, Victoria Aderonke, Lamidi, Ibrahim Yusuf, Ameh, Matthew Phillip, Idoga, Enokela Shaibu, Ubah, Simon Azubuike and Ajayi, Itopa Etudaye (2022). Myrtenal mitigates streptozotocin-induced spatial memory deficit via improving oxido inflammatory, cholinergic and neurotransmitter functions in mice. Current Research in Pharmacology and Drug Discovery, 3 100106, 1-9. doi: 10.1016/j.crphar.2022.100106
Nwosu, Rachel A., Suleiman, Mohammed M., Makun, Hussaina J., Ameh, Matthew P., Shetshak, Manji A. and Akefe, Isaac O. (2021). In vitro anthelmintic activity of Dennettia tripetala G. Baker (Annonaceae) Fruits against Haemonchus contortus. Journal of Parasitic Diseases, 54 (1) 2, 220-229. doi: 10.1007/s12639-021-01438-2
Zakari, Friday Ocheja, Akefe, Isaac Oluwatobi and Uchendu, Chidiebere (2021). Comparison of diurnal rectal and body surface temperatures in large white piglets during the hot-dry season in a tropical Guinea savannah. Journal of Thermal Biology, 99 102953, 1-12. doi: 10.1016/j.jtherbio.2021.102953
Shetshak, M. A., Suleiman, M. M., Jatau, I. D., Ameh, M. P. and Akefe, I. O. (2021). Anticoccidial efficacy of Garcinia kola (Heckel H.) against experimental Eimeria tenella infection in chicks. Journal of Parasitic Diseases, 45 (4), 1-15. doi: 10.1007/s12639-021-01389-8
Lamidi, Ibrahim Yusuf, Mikail, Hudu Garba, Adamu, Sani, Akefe, Isaac Oluwatobi, Tijjani, Mohammed Bashir, Salihu, Sabo Isa, Olatunji, Aisha Omobolanle, Hassan, Abdussalam, Daniel, Nubwa and Adegoke, Victoria Aderonke (2021). Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats. Toxicological Research, 37 (4), 473-484. doi: 10.1007/s43188-020-00084-9
Richard, Otolorin Gbeminiyi, Oluwatobi, Akefe Isaac, Tosin, Olufemi Olaolu, Obinna, Esonu Daniel, Isaac, Dunka Hassana, Adanu, Adanu Williams, Audu, Danjuma Friday, Nok, Kia Grace Sabo, Oghenefega, Ovwighose Naomi and Paul, Mshelbwala Philip (2021). COVID-19 Pandemic: A concise appraisal of the current status. International Journal of Tropical Disease and Health, 42 (4) IJTDH.66588, 1-9. doi: 10.9734/ijtdh/2021/v42i430446
Shetshak, Manji Amos, Jatau, Isa Danladi, Suleiman, Muhammed Musa, Ameh, Matthew Philip, Gabriel, Ada and Akefe, Isaac O. (2021). In vitro anticoccidial activities of the extract and fractions of Garcinia kola (Heckel h.) against Eimeria tenella oocyst. Recent Patents on Biotechnology, 15 (1), 76-84. doi: 10.2174/1872208315666210129095213
Gabriel, Ada, Mohammed, Mamman, Magaji, Mohammed Garba, Ofemile, Yusuf Peter, Matthew, Ameh Philip and Akefe, Isaac (2020). In vitro and in vivo neutralizing activity of Uvaria chamae leaves fractions on the venom of Naja nigricollis in albino rat and bovine blood. Recent Patents on Biotechnology, 14 (4), 295-311. doi: 10.2174/1872208314666200903152129
Akefe, Isaac Oluwatobi, Ayo, Joseph Olusegun and Sinkalu, Victor Olusegun (2020). Kaempferol and zinc gluconate mitigate neurobehavioral deficits and oxidative stress induced by noise exposure in Wistar rats. PloS One, 15 (7) e0236251, 1-12. doi: 10.1371/journal.pone.0236251
Lamidi, Ibrahim Yusuf, Hudu, Mikail Garba, Akefe, Isaac Oluwatobi, Adamu, Sani and Salihu, Sabo Isa (2020). Sub-chronic administration of flavonoid fraction Daflon improve lead-induced alterations in delta-aminolevulinic acid dehydratase activity, erythrocytic parameters, and erythrocyte osmotic fragility in Wistar rats. Comparative Clinical Pathology, 29 (5), 955-963. doi: 10.1007/s00580-020-03144-6
Ameh, Matthew P., Mohammed, Mamman, Ofemile, Yusuf P., Mohammed, Magaji G., Gabriel, Ada and Isaac, Akefe O. (2020). Detoxifying action of aqueous extracts of Mucuna pruriens seed and Mimosa pudica root against venoms of Naja nigricollis and Bitis arietans. Recent Patents on Biotechnology, 14 (2), 134-144. doi: 10.2174/1872208313666191025110019
Aderonke, Adegoke Victoria, Aliyu, Haruna Dede, Akefe, Isaac Oluwatob and Nyan, Ezekiel Stephen (2019). Role of Nickel (II) Salicylhydroxamic Acid and its Aniline Adduct as an Antimicrobial Substitute. Biomedical Journal of Scientific & Technical Research, 18 (1). doi: 10.26717/bjstr.2019.18.003098
Ameh, M.P., Jatau, I. D., Akefe, I. O. and Ada, G. (2019). Hematological and Biological Changes in Different Routes of Experimental Trypanosoma BruceiInfection in Albino Rats. Biomedical Journal of Scientific & Technical Research, 13 (5). doi: 10.26717/bjstr.2019.13.002465
Akefe, Isaac O., Yusuf, Ibrahim L. and Adegoke, Victoria A. (2019). C-glycosyl flavonoid orientin alleviates learning and memory impairment by radiofrequency electromagnetic radiation in mice via improving antioxidant defence mechanism. Asian Pacific Journal of Tropical Biomedicine, 9 (12), 518-523. doi: 10.4103/2221-1691.271725
Akefe, I. O. (2017). Pathophysiological mechanism of intestinal gas production. Biomedical Journal of Scientific and Technical Research, 1 (7). doi: 10.26717/bjstr.2017.01.000606
AO, Isaac, AO, Joseph, SO, Victor, YI, Lamidi and AM, Andrew (2017). Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress. Insights in Biomedicine, 02 (03). doi: 10.21767/2572-5610.10031
Akefe, Isaac O., OA, Joseph and OS, Victor (2017). Mitigative Effects of Antioxidants in Noise Stress. Journal of Clinical Nutrition & Dietetics, 03 (03). doi: 10.4172/2472-1921.100056
Adamu, Andrew, Dung, Edward, Abraham, Solomon, Akefe, Isaac and Yusuf, Ibrahim (2017). The cortisol steroid levels as a determinant of health status in animals. Journal of Proteomics and Bioinformatics, 10 (11). doi: 10.4172/jpb.1000452
Thesis
Akefe, Isaac (2022). Identifying key changes in brain free fatty acids associated with memory in health, ageing and disease: A mechanistic study. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/a5c754a